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Prognostic and predictive value of p53

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Published by Elsevier in Amsterdam, New York .
Written in English


  • p53 antioncogene -- Congresses.,
  • Neoplasms -- genetics -- congresses.,
  • Neoplasms -- therapy -- congresses.,
  • Genes, p53 -- congresses.,
  • Prognosis -- congresses.,
  • Predictive Value of Tests -- congresses.

Book details:

Edition Notes

Includes bibliographical references and index.

Statementedited by Jan G.M. Klijn.
SeriesEuropean School of Oncology scientific updates ;, v. 1
ContributionsKlijn, Jan G. M., European School of Oncology.
LC ClassificationsRC268.44.P16 P76 1997
The Physical Object
Paginationx, 163 p. :
Number of Pages163
ID Numbers
Open LibraryOL682647M
ISBN 10044482832X
LC Control Number97029349

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title = "Prognostic and predictive value of TP53 mutations in human cancer", abstract = "Finding reliable molecular markers for early diagnosis, prognosis and prediction of response to treatment is a major challenge for cancer by: If the address matches an existing account you will receive an email with instructions to reset your passwordAuthor: Mohammed Akhtar. Request PDF | TP53 Somatic Mutations: Prognostic and Predictive Value in Human Cancers | The tumor suppressor gene TP53 (OMIM #) is one of Author: Magali Olivier.   The prognostic and predictive value of p53 has been extensively studied in breast cancer. p53 serves a multifunctional role as a transcriptional regulator, genomic stabilizer, inhibitor of cell cycle progression, facilitator of apoptosis, and also perhaps an inhibitor of angiogenesis. Abrogation of its function should therefore lead to a more aggressive breast cancer phenotype and a worse Cited by:

Purpose The aims of the TP53 Colorectal Cancer (CRC) International Collaborative Study were to evaluate the possible associations between specific TP53 mutations and tumor site, and to evaluate the prognostic and predictive significance of these mutations in different site, stage, and treatment subgroups. Patients and Methods A total of 3, CRC patients from 25 different research groups in Cited by: Kucera E, Speiser P, Gnant M, Szabo L, Samonigg H, Hausmaninger H, Mittlbock M, Fridrik M, Seifert M, Kubista E, Reiner A, Zeillinger R, Jakesz R. Prognostic significance of mutations in the p53 gene, particularly in the zinc-binding domains, in lymph node- and Cited by: Purpose p53 and RAS are multifunctional proteins that are critical to cell cycle regulation, apoptosis, cell survival, gene transcription, response to stress, and DNA repair. We have evaluated the prognostic and predictive value of p53 gene/protein aberrations using tumor samples from JBR, a North American phase III intergroup trial that randomly assigned patients with completely Cited by: Results. Patients with a predicted functional p53 had a better prognosis than patients with non functional p53 (Log Rank p=). Expression of CSNK1A1 modified p53 survival effects. Patients with low CSNK1A1 expression and non-functional p53 had a very poor survival both in the univariate (Log Rank pCited by:

Prognostic value of p53 alterations was determined by risk ratio (RR). The data showed that ppositive immunostaining tended to associate with decreased 2-year survival rates (RR, ; 95% CI, to ; p Cited by: Prognostic and Predictive Factors in Breast Cancer - CRC Press Book This title reviews the key prognostic factors in breast cancer, discussing the methodologies involved in measuring and reporting. It also examines the roles of major predictive markers such as the steroid receptors, p53 and HER A number of retrospective studies have now demonstrated the prognostic value of P53 status for patients with superficial transitional cell carcinoma of the bladder. Patients with greater than 20 percent nuclear staining for P53 are at higher risk for tumor progression and recurrence. The complexity of p53 regulation and the biological functions of a defined p53 mutant in different tumor types resemble a complex barcode. 3 The true prognostic and predictive values of individual p53 mutations will only be accurately evaluated once we can decipher the regulatory barcodes of both wild-type and mutant p